By Aditya Aryan, Health Consultant
Montelukast, a widely prescribed medication for asthma and allergies, is under scrutiny following new findings that reveal its presence in the brain. Known for managing respiratory conditions, the drug has been increasingly associated with side effects such as depression, aggression, and even suicidal thoughts.
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The recent study, presented at a conference in Texas, has raised questions about how montelukast impacts mental health, especially in vulnerable populations. Here’s a closer look at the drug, its benefits, and the growing concerns surrounding its use.
What Is Montelukast?
Montelukast is a leukotriene receptor antagonist used to manage:
- Asthma symptoms, including wheezing and shortness of breath.
- Seasonal allergies, such as hay fever.
It works by blocking leukotrienes, chemicals in the body that trigger inflammation and airway constriction.
The New Findings
Scientists have discovered traces of montelukast in the brain, sparking concerns about its potential effects on the central nervous system. The findings coincide with reports of psychological side effects in some patients, including:
- Depression
- Mood swings
- Suicidal ideation
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While these side effects are listed on product labels, the study suggests a need for more robust warnings and further research to understand the mechanisms involved.
Mental Health Risks
Patients and healthcare providers have reported cases where montelukast triggered significant psychological effects, especially in children and young adults. These include:
- Aggression: Increased irritability and outbursts.
- Sleep Disturbances: Insomnia or vivid dreams.
- Behavioral Changes: Uncharacteristic withdrawal or hyperactivity.

What Should Patients Do?
For Those Currently Taking Montelukast:
- Monitor Symptoms: Pay attention to any mood changes, especially in children.
- Consult Your Doctor: Discuss alternative medications if side effects occur.
- Avoid Abrupt Discontinuation: Stopping the drug suddenly can worsen asthma symptoms.
Safer Alternatives:
- Inhaled corticosteroids
- Antihistamines for allergy relief
FAQs
1. Why is montelukast prescribed despite its risks?
Montelukast is effective for managing asthma and allergies, especially in patients who don’t respond well to inhalers.
2. Are children more at risk?
Yes, children are more susceptible to psychological side effects, making monitoring crucial.
3. How common are these side effects?
Studies suggest they occur in a small percentage of users, but the severity has prompted further investigation.
4. What should I do if I suspect side effects?
Contact your healthcare provider immediately to discuss symptoms and alternative treatments.
5. Are researchers developing safer options?
Yes, ongoing research aims to create effective drugs with minimal mental health impacts.
Montelukast remains a critical tool in asthma management, but patients and healthcare providers must remain vigilant about its potential risks. Always consult a medical professional before making changes to your treatment plan.
Aditya Aryan
Health Consultant and Blogger